Topic: Sibutramine is an appetite suppressant that was indicated as an adjunct treatment of obesity. In 2010, it was withdrawn from the market by the Australian TGA and other drug regulatory agencies worldwide due to serious safety concerns. Discuss the grounds of these concerns with literature evidence that justify the authorities� decision.
Your assignment should consist of a report detailing:  A summarized review of the pharmacology and toxicology of sibutramine, including
indications, adverse effects, contraindications and drug interactions.  The therapeutic roles and dangers of using sibutramine including the postulated
mechanisms of action.
Word limit and requirements: 1500 � 200 words; font size 12; single line spacing
Referencing system: Reference sources should be formatted in the Vancouver style. Example: In text ref should be with superscript numbers.
Analysis and evaluation of literature 40% Critical engagement with the topic 20% Linkage of pharmacological principles to therapeutic outcomes 20% Literacy and written communication skills 10% Presentation and referencing 10%
Mechanism of action:
acts on CNS by Inhibiting reuptake of Serotonin & norepenephrine reuptake to stimulate thermogenesis & feeling of satiety.
from Australian Medicines Handbook:
Contraindications against: psychiatric illnesses (bulimia, anorexia), medical conditions or medication susceptible to increase in heart rate and blood pressure or induce serotonin toxicity, renal/hepatic impairment
Adverse effects: increase HR, Increase BP, nausea, constipation, dry mouth, taste disturbances,, dizziness, paraethesia, sweating, headache, tachycardia, insomnia, anxiety.
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